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HPK1-IN-33

SKU: orb1744397

Description

HPK1-IN-33 (compound 21) is a potent and selective HPK1 inhibitor with a K_i of 1.7 nM. It demonstrates functional activity by inhibiting IL-2 production in Jurkat WT cells (EC_50 = 286 nM), an effect absent in HPK1 KO cells. This inhibitor is a valuable tool for probing HPK1's role in T-cell signaling and immune regulation in both cellular and in vivo research contexts.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number2920000-86-6
MW370.81
FormulaC18H16ClFN6
SMILESN#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CC[C@@H](F)[C@@H](N)C4)c23)c1
TargetOthers,MAPK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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HPK1-IN-33 (orb1744397)

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