Human Kallikrein 8 / KLK-8 Protein, His Tag (active enzyme, MALS verified)

SKU: orb3158182

Description

Kallikrein 8 (KLK8), also known as Neuropsin, PRSS19, or TADG-14, is a member of the human kallikrein-related peptidase family located on chromosome 19. It is a secreted serine protease with strong expression in the hippocampus, where it regulates synaptic plasticity, learning, and memory through cleavage of extracellular matrix proteins and neural adhesion molecules. KLK8 has also been implicated in skin physiology, including keratinocyte proliferation and desquamation. Abnormal expression of KLK8 has been reported in several cancers, such as ovarian and colorectal cancer, making it a potential biomarker and therapeutic target2.

Images & Validation

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Application Notes	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.8 kDa. The protein migrates as 32-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

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Expression System	HEK293
Target	Kallikrein 8
Reactivity	Human
Tag	C-10×His
Molecular Weight	26.8 kDa
Expression Region	Gln 29 - Gly 260
Purity	95%
Endotoxins	1.0 EU per μg
Conjugation	Unconjugated

Storage & Handling

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Storage	-20°C
Form/Appearance	Powder
Buffer/Preservatives	50 mM Tris, 150 mM NaCl, pH 8.5
Expiration Date	6 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

Kallikrein 8

RefSeq:O60259

NCBI Reference Sequences

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Associated Accession Numbers

Curated reference sequences for the gene transcript and protein product

RefSeq	O60259

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