Human Kallikrein 9 Protein, His Tag

SKU: orb3158183

Description

Kallikrein 9 (KLK9) is a member of the human tissue kallikrein-related peptidase family, encoded by the KLK9 gene on chromosome 19q13.41. It is a secreted serine protease synthesized as an inactive zymogen and activated by proteolytic cleavage. KLK9 is expressed in several tissues, including the brain, skin, and reproductive organs, and is thought to participate in extracellular matrix remodeling and epithelial homeostasis. Biochemical studies show that KLK9 is a chymotrypsin-like enzyme with preference for tyrosine at the P1 site, regulated by metal ions and protease inhibitors. Dysregulated KLK9 expression has been linked to cancers and inflammatory conditions, suggesting potential biomarker and therapeutic relevance.

Images & Validation

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Application Notes	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.9 kDa. The protein migrates as 35-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

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Expression System	HEK293
Target	Kallikrein 9
Reactivity	Human
Tag	C-10×His
Molecular Weight	27.9 kDa
Expression Region	His 16 - Asn 250
Purity	90%
Endotoxins	1.0 EU per μg
Conjugation	Unconjugated

Storage & Handling

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Storage	-70°C
Form/Appearance	Liquid
Buffer/Preservatives	20 mM HEPES, 150 mM NaCl, pH 7.5
Expiration Date	6 months from date of receipt.
Dry Ice Shipping	Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

Kallikrein 9

RefSeq:Q9UKQ9

NCBI Reference Sequences

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Associated Accession Numbers

Curated reference sequences for the gene transcript and protein product

RefSeq	Q9UKQ9

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