Human Plasma Kallikrein / KLKB1 Protein, His Tag (Pro-form, MALS verified)

SKU: orb1496197

Description

Human Plasma Kallikrein, a serine protease, is synthesized in the liver and circulates in the plasma by binding to high molecular weight (HMW) kininogen or as a free zymogen. The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

Images & Validation

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Application Notes	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 71.1 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

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Source	Human Plasma Kallikrein/KLKB1, His Tag (orb1496197) is expressed from human 293 cells (HEK293). It contains AA Gly 20 - Ala 638 (Accession # P03952-1).
Expression System	HEK293
Target	Plasma Kallikrein/KLKB1
Reactivity	Human
Tag	C-10×His
Molecular Weight	71.1 kDa
Expression Region	Gly 20 - Ala 638
Purity	95%
Endotoxins	1.0 EU per μg
Conjugation	Unconjugated

Storage & Handling

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Storage	-70℃
Form/Appearance	Liquid
Buffer/Preservatives	50mM Tris 150mM NaCl,PH7.5
Expiration Date	6 months from date of receipt.
Dry Ice Shipping	Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
Disclaimer	For research use only

Alternative Names

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Fletcher factor,kallikrein B, plasma (Fletcher factor) 1,kininogenin,KLK3plasma kallikrein,KLKB1,plasma kallikrein heavy chain,plasma kallikrein light chain,Plasma Kallikrein,Plasma Prekallikrein,PPK，KLKB1

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Quick Database Links

Gene Symbol

Plasma Kallikrein/KLKB1

UniProt

P03952

RefSeq:P03952

UniProt Details

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No UniProt data available

NCBI Reference Sequences

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Associated Accession Numbers

Curated reference sequences for the gene transcript and protein product

RefSeq	P03952

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