Hyaluronic acid

SKU: orb1303782

Description

Hyaluronic acid is a glycosaminoglycan composed of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine. It is a key extracellular matrix component in connective tissues, synovial fluid, and the vitreous humor, widely used in research on cell migration, wound healing, and tissue hydration in both in vitro and in vivo models.

Research Area

Infectious Disease & Virology, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	9004-61-9
MW	800000~1500000
Purity	≥98% (May vary between batches)
Formula	(C₁₄H₂₁NO₁₁)n
SMILES	[N].CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](CO)O[C@@H](C)[C@@H]2NC(C)=O)O[C@@H]1C(O)=OjcExt:v:0:0
Target	Endogenous Metabolite,Antibacterial,Akt,PI3K
Solubility	H2O:14.29 mg/mL

Bioactivity

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In Vivo

HA (hyaluronic acid) is ubiquitous across biological fluids and tissues, with its beneficial effects on joint health evidenced by numerous animal studies. These studies have demonstrated that HA enhances cartilage matrix synthesis, prevents its degradation, mitigates inflammation, fosters the production of endogenous HA, and augments cartilage resilience and hydration. Additionally, topically applied high molecular weight HA formulations have been shown to expedite the healing of acute skin wounds and facilitate the recovery of venous leg ulcers, thereby offering a valuable option for chronic wound management.

In Vitro

Hyaluronic acid (HA) is extensively utilized across various medical fields due to its capacity to bind with numerous water molecules, thereby enhancing tissue hydration and mechanical resistance. Its significant roles include facilitating wound healing, ovulation, fertilization, signal transduction, and impacting tumor physiology, making it valuable in aesthetic medicine, joint disorder treatments like osteoarthritis and rheumatoid arthritis, and ophthalmology for its lubricative benefits on the corneal endothelium. High molecular mass HA impairs the chemotaxis and migration of inflammatory cells, thus serving as an effective barrier to inflammation and shielding from free radicals. Furthermore, HA contributes to aesthetic dermatology by minimizing mechanical damage to tissues with minimal side effects. Research also suggests its potential in identifying tumor markers, managing liver diseases, and application in pharmaceutical formulations. In cancer research, particularly digestive cancers, HA interactions with tumor cells may activate signaling pathways that promote proliferation, cell adhesion, migration, invasion, and contribute to angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, stem cell-like characteristics, and resistance to chemotherapy and radiation.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Inhibitor, Endogenous Metabolite, EndogenousMetabolite, Hyaluronic acid, Hyaluronate, hyaluronan

Quality Guarantee

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Compound Identifiers

PubChem CID

137699088 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

Applications:	IF, IHC-Fr, IHC-P
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Recombinant
Conjugation:	Unconjugated

Applications:	ICC, IF, IHC, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	WB
Predicted Reactivity:	Bovine, Porcine, Sheep
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	IHC-P, WB
Reactivity:	Human, Mouse
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	FC, WB
Predicted Reactivity:	Bovine, Equine, Gallus, Mouse, Porcine, Rabbit, Rat, Sheep
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Hyaluronic acid

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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