Hypoxanthine

SKU: orb1308844

Description

Hypoxanthine (Purin-6-ol) is a natural purine derivative and a key metabolic intermediate in nucleotide salvage pathways. It is widely used in research on purine metabolism, enzymology (e.g., xanthine oxidase studies), and as a biomarker in models of ischemia and oxidative stress, both in vitro and in vivo.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	68-94-0
MW	136.11
Purity	99.86% (May vary between batches)
Formula	C₅H₄N₄O
SMILES	OC1=NC=NC2=C1N=CN2
Target	Endogenous Metabolite
Solubility	DMSO:5 mg/mL (36.73 mM);Ethanol:Insoluble

Bioactivity

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In Vivo

A linear increase of plasma hypoxanthine with duration of hypoxemia is found in pigs, and there is no difference between arterial and venous plasma. There are good correlations between hypoxanthine and lactate, base deficit and pH. Moreover, there is a direct relationship between survival time and an increase in plasma hypoxanthine. Survival time correlates negatively with the rate of hypoxanthine increase (r=-0.62). All animals die when hypoxanthine exceeds 125 pM/liter. The increase of hypoxanthine, thus, reflected the prognosis of acute hypoxia in contrast to base deficit.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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EndogenousMetabolite, Endogenous Metabolite, Hypoxanthine, Inhibitor, inhibit, 6-Hydroxypurine, Sarcine, Sarkin, Purine nucleoside phosphorylase, Purin-6-ol

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Compound Identifiers

PubChem CID

135398638 ↗

Key Properties

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No computed properties available.

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Hypoxanthine (orb1308844)

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Applications:	ICC, IHC-P, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	FC, IHC-P, WB
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Reactivity:	Human
Dynamic Range:	0.16-10 ng/mL
Sensitivity:	0.058 ng/mL

Reactivity:	Mouse
Dynamic Range:	0.16-10 ng/mL
Sensitivity:	0.059 ng/mL

Applications:	FC, IHC-P, WB
Predicted Reactivity:	Hamster, Mouse, Porcine, Rat
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Hypoxanthine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Key Properties

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Hypoxanthine (orb1308844)

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