I-CBP112 hydrochloride

SKU: orb1303026

Description

I-CBP112 is a potent and selective small molecule inhibitor of the CBP/p300 bromodomains. It reduces the leukemia-initiating potential of MLL-AF9+ AML cells in vitro and in vivo and shows synergistic effects with BET inhibitors like JQ1 and chemotherapeutics such as doxorubicin in oncology research.

Research Area

Epigenetics & Chromatin

Images & Validation

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Key Properties

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CAS Number	2147701-33-3
MW	505.05
Purity	99.69% (May vary between batches)
Formula	C₂₇H₃₇ClN₂O₅
SMILES	O(C[C@@H]1CN(C)CCC1)C2=C3C(=CC(=C2)C4=CC(OC)=C(OC)C=C4)CN(C(CC)=O)CCO3.Cl
Target	Epigenetic Reader Domain
Solubility	DMSO:60 mg/mL (118.8 mM)

Bioactivity

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In Vivo

I-CBP112 markedly and dose-dependently reduces the leukemia-initiating potential of mLL-AF9+ AmL cells in vitro and in vivo. The synergistic effects of I-CBP112 and current standard therapy (doxorubicin), as well as emerging treatment strategies (BET inhibition), provide new possibilities for combinatorial treatment of leukemia and potentially other cancers.

Storage & Handling

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Storage	Pure form: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CBP/p300, Leukemia cell, CBP/p300, Prostate cancer cell, Inhibitor, I-CBP 112 Hydrochloride, I-CBP112, ICBP112 hydrochloride, I-CBP112 Hydrochloride, I-CBP-112 hydrochloride, I-CBP-112 Hydrochloride, I CBP112 hydrochloride, Epigenetic Reader Domain, EpigeneticReaderDomain, inhibit

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Compound Identifiers

PubChem CID

132285145 ↗

Key Properties

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No computed properties available.

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