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Icotrokinra

SKU: orb2664463

Description

Icotrokinra is a potent, orally active, and selective IL-23 receptor antagonist that blocks IL-23 signaling, evidenced by inhibiting STAT3 phosphorylation (IC50 = 5.6 pM) in PBMCs and reducing IFN-γ production in NK cells. Its anti-inflammatory efficacy, demonstrated in a rat TNBS-colitis model, supports research into psoriasis, psoriatic arthritis, and inflammatory bowel disease.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2763602-16-8
MW1898.17
Purity98.93%
FormulaC90H120N20O22S2
SMILESN(C([C@H](CC1=CC2=C(C=C1)C=CC=C2)NC([C@H](CC3=CC=C(OCCN)C=C3)NC(=O)[C@H]4NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CC=5C=6C(NC5)=C(C)C=CC6)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(C)=O)C(C)(C)SSC4(C)C)[H])=O)=O)C7(C(N[C@H](C(N[C@H](C(N[C@@H](CC=8C=CC=NC8)C(N(CC(N)=O)C)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)CCOCC7
TargetIL Receptor
SolubilityH2O:≥ 80 mg/mL;DMSO:80 mg/mL (42.15 mM)

Bioactivity

Target IC50
IL-23:7.1 pM (Kd)
In Vivo
In the TNBS-induced rat colitis model, oral administration of Icotrokinra at doses ≥0.3 mg/kg/day significantly reduced body weight loss and the colon weight/length ratio. In the IL-23-induced skin inflammation model, Icotrokinra at doses ≥10 mg/kg BID markedly suppressed IL-17A, IL-17F, and IL-22 gene expression and alleviated skin thickness.

Storage & Handling

Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JNJ2113, JNJ-2113, JNJ77242113, JNJ-77242113, PN235, PN-235

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Key Properties

No computed properties available.

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Icotrokinra (orb2664463)

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