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IKK16

SKU: orb2655984

Description

IKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively; inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM with IC50 of 1.0, 0.5, 0.3 and 0.3 uM respectively; inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis models.

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Key Properties

CAS Number1186195-62-9
MW535.107
Purity>98% (HPLC)
FormulaC28H31ClN6OS
SMILESC1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl
TargetIκB kinase (IKK)
SolubilityIn Vitro: DMSO : 100 mg/mL (192.27 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

IKK 16

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IKK16 (orb2655984)

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