Cart summary

You have no items in your shopping cart.

IL-4-inhibitor-1

SKU: orb1693654

Description

This small molecule IL-4 inhibitor selectively binds IL-4 (Kd = 1.8 µM) to block the IL-4/JAK1/STAT6 signaling pathway, as demonstrated by its inhibition of IL-4-induced STAT6 phosphorylation in THP-1 cells. It is a valuable research tool for studying type 2 immune responses in asthma and allergy models, both in vitro and in vivo.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number1332184-63-0
MW321.31
Purity>99.99% (May vary between batches)
FormulaC18H12FN3O2
SMILESNc1nc(cc(-c2ccc(O)c(O)c2)c1C#N)-c1ccc(F)cc1
TargetInterleukin,IL Receptor
SolubilityEthanol:10 mg/mL (31.12 mM);DMF:27 mg/mL (84.03 mM);DMSO:PBS (pH 7.2) (1:5):0.1 mg/mL (0.31 mM);DMSO:50 mg/mL (155.61 mM)

Bioactivity

Target IC50
IL-4:1.81 µM (EC50)
In Vitro
IL-4-inhibitor-1 exhibits functional disruption of type II IL-4 binding in a cellular context and dose-dependent reduces pSTAT-6 levels (EC50 = 3.1 µM).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

IL4inhibitor1, IL-4-inhibitor-1, IL-4, ILReceptor, IL Receptor, IL 4 inhibitor 1
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

IL-4-inhibitor-1 (orb1693654)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 190.00
5 mg
$ 230.00
10 mg
$ 390.00
25 mg
$ 630.00
50 mg
$ 890.00
100 mg
$ 1,200.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry