Cart summary

You have no items in your shopping cart.

IOWH-032

SKU: orb1226844

Description

A novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis; potentially serves as lead compound for development of new drugs for the treatment of cystic fibrosis.(In Vitro):IOWH-032 (10 μM; 0-72 h) increases the ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells.

Images & Validation

Key Properties

CAS Number1191252-49-9
MW545.1802
Purity>98% (HPLC)
FormulaC22H15Br2N3O4
SMILESO=C(C1=NC(C2=CC(Br)=C(O)C(Br)=C2)=NO1)NCC3=CC=C(OC4=CC=CC=C4)C=C3
TargetCFTR
Solubility10 mM in DMSO

Bioactivity

In Vitro
IOWH-032 (10 μM; 0-72 h) increases the ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells. Western blot analysis. Cell line: CFBE41o- cells. Concentration: 10 μM. Incubation time: 0, 24, 48, 72 h. Result: Increased the ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells in a time-dependent manner.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

iOWH-032 | IOWH032 | IOWH 032

Similar Products

  • IOWH-032 [orb1305411]

    >99.99% (May vary between batches)

    1191252-49-9

    545.18

    C22H15Br2N3O4

    50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 10 mg, 25 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

IOWH-032 (orb1226844)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

200 mg
500 mg
10 mg
$ 100.00
25 mg
$ 150.00
50 mg
$ 220.00
100 mg
$ 320.00