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Zomiradomide

SKU: orb1982288

Description

Zomiradomide is an orally bioavailable PROTAC that induces degradation of IRAK4, IKZF1, and IKZF3. This dual action suppresses NF-κB signaling and activates type I interferon pathways, demonstrating anticancer efficacy in B-cell lymphoma models in preclinical research.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number2655656-99-6
MW871.97
Purity98.41%
FormulaC45H48F3N7O6S
SMILESC(N1CC2(C1)CC(CCNC3=C4C(C(=O)N(C4=O)C5C(=O)NC(=O)CC5)=CC=C3)C2)[C@H]6CC[C@@H](CC6)C=7SC=8C(N7)=CC(C(C)(C)O)=C(NC(=O)C=9N=C(C(F)(F)F)C=CC9)C8
TargetIKZF,IRAK,PROTACs,IFNAR,NF-κB
Solubility2% DMSO+40% PEG300+5% Tween 80+53% Saline:3 mg/mL (3.44 mM);DMSO:150 mg/mL (172.02 mM)

Bioactivity

In Vivo
Method: In OCI-Ly10 xenograft mouse models, Zomiradomide was administered orally at doses of 3–30 mg/kg once daily for 3 consecutive days to evaluate its antitumor effect. Result: Zomiradomide significantly inhibited tumor growth.
In Vitro
Method: The diffuse large B-cell lymphoma (DLBCL) cell line OCI-Ly10 carrying the Myd88 L265P mutation was treated with various concentrations of Zomiradomide to assess its antiproliferative effect and determine the IC₅₀ value. Result: Zomiradomide effectively inhibited the proliferation of OCI-Ly10 cells, with an IC₅₀ of 11 nM.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

IRAK degrader-1, KT413, KT-413, T75136
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Zomiradomide (orb1982288)

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1 mg
$ 200.00
5 mg
$ 330.00
10 mg
$ 470.00
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