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IRG1-IN-1

SKU: orb2278558

Description

IRG1-IN-1 is an itaconate-derived inhibitor of Immune Responsive Gene 1 (IRG1). It is a valuable research tool for studying the role of IRG1 and itaconic acid metabolism in models of cancer, inflammation, and autoimmune diseases, applicable in both in vitro and in vivo experimental settings.

Images & Validation

Key Properties

CAS Number2407652-42-8
MW314.31
Purity99.69% (May vary between batches)
FormulaC18H15FO4
SMILESO=C(O)C(=CC1=CC=C(F)C=C1)C(C(=O)O)CC=2C=CC=CC2
TargetOthers
SolubilityDMSO:80 mg/mL (254.53 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.5 mM)

Bioactivity

In Vivo
IRG1-IN-1 administered intraperitoneally at a dose of 0.2 mg/kg for 27 days demonstrates a significant anti-tumor effect in C57BL/6 mice .
In Vitro
IRG1-IN-1 (0.5 mM; 1 mM) partially inhibits the proliferation of C-IRG1-9 rat glioma cells . IRG1-IN-1 (0.5 mM; 2 mM) reduces the production of itaconic acid and the secretion of TNFα from human monocyte-derived macrophages (hMDMs) stimulated with LPS .IRG1-IN-1 (10μM) shows a decrease in trimethylation of histone 3 at lysine 4 (H3K4me3) in CR-activated hCD8+ T cells . IRG1-IN-1 (10 nM) increases the proliferation of TCR-activated hCD8+ T cells .

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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IRG1-IN-1 (orb2278558)

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1 mg
$ 100.00
DispatchUsually dispatched within 5-10 working days
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