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Description

IS4 is a selective competitive antagonist of CXCR4, exhibiting an IC50 of 0.65 nM in THP-1 cells and 38.75 nM in Jurkat cells. It remains stable in serum and is non-cytotoxic. IS4 competes with CXCL12 for binding to CXCR4, thereby inhibiting CXCL12-induced intracellular Ca2+ release and cancer cell migration. This compound is applicable in research on the prevention of metastasis in conditions such as breast cancer, prostate cancer, and leukemia.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Images & Validation

Key Properties

TargetCXCR
CAS Number3067986-23-3
MW1075.22
FormulaC48H62N14O11S2
SMILESO=C1C2=C(C(=O)N1CC#C)SC[C@@H](C(O)=O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](NC([C@@H](NC([C@H](CCCNC(=N)N)NC(C)=O)=O)C)=O)CS2

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

Protein Handling and Storage Guide
Protein Handling Guide
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IS4 (orb3142509)

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