ISAM-CG557

ISAM-CG557 is a selective CB2R agonist with a Ki of 54.6 nM. It reduces intracellular ROS levels and caspase activity, demonstrating significant MAPK bias and moderate G-protein bias, with CB2REC50 values of 0.60 nM for cAMP, 60.9 nM for β-arrestin, and 0.03 nM for MAPK. ISAM-CG557 exerts potent anti-inflammatory effects by decreasing pro-inflammatory cytokines and increasing anti-inflammatory cytokines in cells. It is utilized in the study of neuroinflammation and neurodegenerative diseases.