ISO-1

SKU: orb1223117

Description

ISO-1, also known as MIF Antagonist and ISO-1 and Macrophage Migration Inhibitory Factor, is a MIF inhibitor. ISO-1 has CAS#478336-92-4. MDK-6924 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment. Systemic administration of the MIF inhibitor ISO-1 significantly blocked photoreceptor apoptosis, outer nuclear layer (ONL) thinning, and retinal gliosis. ISO-1 and MIF knockout (MIFKO) had greater accumulation of Müller glia pERK expression in the detached retina, suggesting that Müller survival pathways might underlie the neuroprotective response.

Images & Validation

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Key Properties

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CAS Number	478336-92-4
MW	235.2
Purity	>98% (HPLC)
Formula	C₁₂H₁₃NO₄
SMILES	COC(=O)CC1CC(=NO1)c1ccc(O)cc1
Target	MIF
Solubility	DMSO : ≥ 36 mg/mL; 153.04 mM

Bioactivity

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In Vivo

ISO-1 (injected intraperitoneally; 3.5-35 mg/kg; twice daily; 2 weeks) improves the survival rate from lethal endotoxemia and shows the anti-inflammatory effect. ISO-1 (intraperitoneal injection; 35 mg/kg; twice daily; 3 days) causes a significant reduction in average implant size and decreases Flk1 expression in implants. Animal model: C57Bl/6 MIF+/+ and MIF–/– mice. Dosage: 3.5-35 mg/kg. Administration: Injected intraperitoneally; 3.5-35 mg/kg; twice a day; 2 weeks. Result: Was protective against lethal sepsis. Animal model: Female C57BL/6-Tg(ACTB-EGFP)1Osb/J mice. Dosage: 35 mg/kg. Administration: Intraperitoneal injection; 35 mg/kg; twice daily; 3 days. Result: Reduced average endometriotic implant size.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ISO-1 | ISO 1 | ISO1 | MIF Antagonist

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MIF

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ISO-1 (orb1223117)

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Applications:	ELISA, WB
Reactivity:	Bacteria
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Purity:	98.65%
CAS Number:	478336-92-4
MW:	235.24
Formula:	C₁₂H₁₃NO₄

ISO-1

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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ISO-1 (orb1223117)

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