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ISO-1

SKU: orb1303909

Description

ISO-1 is a small molecule MIF antagonist that inhibits dopachrome tautomerase activity. It suppresses NF-κB activation and TNF-α secretion in LPS-stimulated macrophages, making it a valuable tool for studying inflammation, sepsis, and autoimmune diseases in both cellular and animal models.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number478336-92-4
MW235.24
Purity98.65%
FormulaC12H13NO4
SMILESCOC(=O)CC1CC(=NO1)c1ccc(O)cc1
TargetOthers,MIF
SolubilityDMSO:45 mg/mL (191.29 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.5 mM)

Bioactivity

Target IC50
MIF:7 μM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

dopachrome tautomerase, MIF Antagonist, inhibit, ISO 1, ISO1, ISO-1, Inhibitor

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Key Properties

No computed properties available.

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ISO-1 (orb1303909)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 110.00
5 mg
$ 110.00
10 mg
$ 140.00
25 mg
$ 230.00
50 mg
$ 370.00
100 mg
$ 560.00
500 mg
$ 920.00
1 g
$ 1,270.00
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