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ISO-1

SKU: orb1303909

Description

ISO-1 is a small molecule MIF antagonist that inhibits dopachrome tautomerase activity. It suppresses NF-κB activation and TNF-α secretion in LPS-stimulated macrophages, making it a valuable tool for studying inflammation, sepsis, and autoimmune diseases in both cellular and animal models.

Research Area

Cell Biology, Neuroscience

Images & Validation

Key Properties

CAS Number478336-92-4
MW235.24
Purity>98%
FormulaC12H13NO4
SMILESCOC(=O)CC1CC(=NO1)c1ccc(O)cc1
TargetOthers,MIF
SolubilitySoluble in DMSO (up to 25 mg/ml).

Bioactivity

Target IC50
MIF:7 μM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

dopachrome tautomerase, MIF Antagonist, inhibit, ISO 1, ISO1, ISO-1, Inhibitor

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Key Properties

No computed properties available.

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Protocol Information

ISO-1 (orb1303909)

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5 mg
$ 190.00
25 mg
$ 380.00
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