Isobavachromene

SKU: orb1297329

Description

Isobavachromene is a bioactive small molecule that inhibits both NADH-Ubiquinone oxidoreductase (Complex I) and ornithine decarboxylase. This dual inhibitory activity underlies its observed antifungal properties, making it a useful research tool for studying mitochondrial function, polyamine biosynthesis, and antifungal mechanisms in vitro.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	52801-22-6
MW	322.35
Purity	99.79% (May vary between batches)
Formula	C₂₀H₁₈O₄
SMILES	CC1(C)Oc2ccc(C(=O)\C=C\c3ccc(O)cc3)c(O)c2C=C1
Target	Antibacterial
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.2 mM);DMSO:25 mg/mL (77.56 mM)

Bioactivity

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In Vitro

Estrogenic activities of ethanol extract and its active components from Psoralea corylifolia L. were studied using various in vitro assays. The main components from ethanol extract were analyzed to be bakuchiol, psoralen, isobavachalcone, Isobavachromene, and bavachinin. In a fractionation procedure, hexane and chloroform fractions showed estrogenic activity in yeast transactivation assay and E-screen assay. In yeast transactivation assay, ethanol extract, hexane, and chloroform fractions showed significantly higher activities at a concentration of 1.0 ng/ml, and bakuchiol at the concentration of 10(-6) M was showed the highest activity, especially, which was higher than genistein at the same concentration

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Inhibitor, Estrogen Receptor/ERR, inhibit, mutans, Isobavachromene, Bacterial, BACE, Antibacterial, ornithine decarboxylase, Streptococcus

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Compound Identifiers

PubChem CID

5889042 ↗

Key Properties

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No computed properties available.

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