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Isosilybin B

SKU: orb1684500

Description

Isosilybin B

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry

Images & Validation

Key Properties

CAS Number142796-22-3
MW482.44
Purity99.96%
FormulaC25H22O10
SMILESC(O)[C@H]1[C@@H](OC=2C(O1)=CC(=CC2)[C@H]3OC=4C(C(=O)[C@@H]3O)=C(O)C=C(O)C4)C5=CC(OC)=C(O)C=C5
TargetPSMA,Apoptosis,Caspase,CDK,Androgen Receptor

Bioactivity

In Vivo
Isosilybin B (50 and 100 mg/kg body weight; oral) effectively inhibits the growth of advanced human PCA DU145 xenografts. Immunohistochemical analyses revealed that Isosilybin B inhibit tumor angiogenesis biomarkers (CD31 and nestin) and signaling molecules regulating angiogenesis (VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α±) without adversely affecting the vessel-count in normal tissues (liver, lung, and kidney) of tumor-bearing mice.
In Vitro
Isosilybin B also inhibited the microvessel sprouting from mouse dorsal aortas ex vivo, and the VEGF-induced cell proliferation, capillary-like tube formation, and invasiveness of human umbilical vein endothelial cells (HUVEC) in vitro. Further studies in HUVEC showed that these diastereoisomers target cell cycle, apoptosis, and VEGF-induced signaling cascade. Three-dimensional growth assay as well as co-culture invasion and in vitro angiogenesis studies (with HUVEC and DU145 cells) suggested the differential effectiveness of the diastereoisomers toward PCA and endothelial cells.

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Akt, Androgen Receptor, AndrogenReceptor, Apoptosis, Isosilybin B, Mdm2, PI3K

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Key Properties

No computed properties available.

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Isosilybin B (orb1684500)

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Available Sizes

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1 mg
$ 230.00
1 ml x 10 mM (in DMSO)
$ 260.00
5 mg
$ 440.00
10 mg
$ 620.00
25 mg
$ 1,030.00
50 mg
$ 1,260.00
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