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Itasetron

SKU: orb1703344

Description

Itasetron (U 98079A) is a selective 5-HT3 receptor antagonist. It is utilized in research to investigate age-related memory impairment and chemotherapy-induced emesis in rodent models, supporting studies in neuropharmacology and oncology.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Itasetron

Key Properties

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CAS Number123258-84-4
MW300.36
Purity99.68% (May vary between batches)
FormulaC16H20N4O2
SMILESC(N[C@H]1C[C@@]2(N(C)[C@](C1)(CC2)[H])[H])(=O)N3C=4C(NC3=O)=CC=CC4
Target5-HT Receptor
SolubilityDMSO:45 mg/mL (149.82 mM)

Bioactivity

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In Vivo
Itasetron orally is rapidly absorbed (about 90 min), is highly bioavailable (greater than 90%), and has a long half-life (about 12 h). Itasetron (0.5, 1, 2, 4, and 8 mg; twice daily) in comparison with 8 mg b.i.d. ondansetron. Assessments were made in patients (n = 104) with histologically confirmed cancer (excluding head and neck tumors) and about to receive their first course of moderately emetogenic chemotherapy. Itasetron demonstrated comparable efficacy to ondansetron; no statistically significant between-group differences were observed in the primary (complete response rate) or secondary (nausea and delayed emesis) efficacy criteria. The tolerability of Itasetron was assessed as 'very good' or 'rather good' by 81% of patients and 89% of physicians. In conclusion, Itasetron is effective and well tolerated in patients receiving moderately emetogenic chemotherapy. Oral doses of 1 mg b.i.d. or above will be used in further clinical studies.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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DAU 6215CL, DAU6215CL, 5-HT3, 5HT Receptor, 5HTReceptor, Itasetron, UNII-00S0D0OEKR, U-98079A, U 98079A

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID
6918106 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

Select a size below

1 mg
$ 190.00
5 mg
$ 390.00
10 mg
$ 520.00
25 mg
$ 710.00
50 mg
$ 990.00
100 mg
$ 1,330.00
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