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ITK-IN-6

SKU: orb3135358

Description

ITK-IN-6 is a potent and selective ITK inhibitor (Kd = 387 nM). It binds directly to the ITK kinase domain. This compound prevents the release of pro-inflammatory cytokines and the activation and differentiation of Th2 and Th17 cells. ITK-IN-6 improves asthma progression by reducing inflammatory cell infiltration, mucus production, and IgE generation. It significantly inhibits airway inflammation and is used in asthma research.

Images & Validation

Key Properties

CAS Number2616666-32-9
MW451.32
FormulaC20H16Cl2N2O4S
SMILESO=C(NC1=CC=C(O)C(=C1)NS(=O)(=O)C)C2=CC=C(C=C2)C=3C=CC=C(Cl)C3Cl
TargetTyrosine Kinases

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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ITK-IN-6 (orb3135358)

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