Cart summary

You have no items in your shopping cart.

IU1

SKU: orb1301067

Description

IU1 is a cell-permeable, reversible, and specific inhibitor of the human deubiquitinase USP14, with a reported IC50 of 4.7 µM. It is a valuable research tool for studying proteasome function, protein turnover, and neurodegenerative disease mechanisms in both cellular and biochemical assays.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number314245-33-5
MW300.37
Purity99.30% (May vary between batches)
FormulaC18H21FN2O
SMILESO=C(C=1C=C(N(C2=CC=C(F)C=C2)C1C)C)CN3CCCC3
TargetDUB,Autophagy
SolubilityDMSO:48 mg/mL (159.8 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.33 mM);Ethanol:15 mg/mL (49.94 mM)

Bioactivity

Target IC50
USP14:4.7 μM
In Vitro
IU1 binds specifically to the activated form of USP14. IU1 can potentially inhibit USP14 by preventing its docking on the proteasome, exhibiting little or no activity toward 8 other DUBs, IsoT, UCH37, BAP1, UCH-L1, UCH-L3, USP15, USP2, USP7. USP14 inhibition is rapidly established upon addition of IU1 and rapidly reversed upon its removal. IU1 inhibits USP14 induced chain trimming and decreases electrophoretic mobility of Ub-CCNB species. IU1 enhances proteasomal degradation of Ub-CCNB in the presence of USP14. IU1 promots degradation of tau and depletes TDP-43, ATXN3, and glial fibrillary acidic protein (GFAP) in proteotoxic mechanisms.
Cell Research
MTT(Only for Reference)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

USP14, Inhibitor, inhibit, IU 1, IU1, IU-1, Autophagy, DUBs, Deubiquitinase

Similar Products

  • IU1-248 [orb1298140]

    99.30%

    2307472-03-1

    337.42

    C20H23N3O2

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 200 mg, 1 ml x 10 mM (in DMSO), 100 mg
  • IU1-47 [orb1308181]

    99.55% (May vary between batches)

    670270-31-2

    330.85

    C19H23ClN2O

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 1 ml x 10 mM (in DMSO)
  • IU1 [orb611936]

    >98%

    314245-33-5

    364.933

    IU

    100 mg, 1 g, 250 mg
  • IU-1 [orb1225335]

    >98% (HPLC)

    314245-33-5

    300.377

    C18H21FN2O

    200 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 g, 500 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

IU1 (orb1301067)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 ml x 10 mM (in DMSO)
$ 100.00
5 mg
$ 100.00
10 mg
$ 120.00
25 mg
$ 190.00
50 mg
$ 300.00
100 mg
$ 490.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry