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Ivermectin

SKU: orb1309664

Description

Ivermectin (MK-933) is a research compound that acts as an agonist of glutamate-gated chloride channels (GluCls), leading to its well-characterized antiparasitic effects. It is widely used in in vitro and in vivo studies of parasitology and neuropharmacology to investigate ion channel function and anthelmintic mechanisms.

Research Area

Cell Biology, Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

Key Properties

CAS Number70288-86-7
MW875.09
Purity97.74%
FormulaC48H74O14
SMILESCO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@H](C[C@@H]2OC)O[C@H]2[C@@H](C)\C=C\C=C3/CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O[C@H]5C[C@@H](C\C=C2/C)O[C@@]2(CC[C@H](C)[C@H](O2)C(C)C)C5)[C@]34O)O[C@@H](C)[C@@H]1O.CC[C@@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C\C=C(C)\[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)\C=C\C=C3/CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2
TargetSARS-CoV,Antibacterial,Parasite,Antibiotic,HIV Protease,GluCls,P2X Receptor,Anti-infection,Mitophagy,HSV,Autophagy
SolubilityEthanol:27 mg/mL (30.85 mM);DMSO:257.5 mg/mL (294.26 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

In Vivo
Intraperitoneal injection of Ivermectin (1.25-10 mg/kg) can reduce the consumption of alcohol and saccharin. For mice exposed to lethal doses of LPS, Ivermectin inhibits LPS-induced NF-kB translocation and enhances survival rates.
In Vitro
Ivermectin exhibits antiviral activity against HIV-1 and Dengue fever virus. It binds to a novel site on GABAA receptors in hippocampal embryonic neurons of mice, conformationally enhancing the affinity of the GABA binding site. In nematodes, the compound interacts with glutamate-gated chloride channels (GluCls), disrupting the regulation mediated by GluCl activity.

Storage & Handling

Storagekeep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Ivermectin, inhibit, MK 933, MK933, MK-933, Mitophagy, Mitochondrial Autophagy, Parasite, HIV, HIVProtease, HIV Protease, Herpes simplex virus, Inhibitor, Human immunodeficiency virus, HSV, GluCl channels, Antibiotic, Autophagy, P2XReceptor, P2X4, P2X Receptor, SARS coronavirus, SARSCoV, SARS-CoV

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Ivermectin (orb1309664)

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% DMSO +
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% Tween 80 +
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Available Sizes

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200 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 100.00
500 mg
$ 100.00
1 g
$ 120.00
2 g
$ 140.00
5 g
$ 210.00
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