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IWR-1

SKU: orb1305217

Description

IWR-1-endo is a potent small molecule inhibitor of the Wnt signaling pathway with an EC50 of 0.2 µM, functioning by stabilizing the Axin destruction complex. It is widely used in biochemical and cellular research, including studies of stem cell differentiation and cancer biology, both in vitro and in vivo.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1127442-82-3
MW409.44
Purity99.82% (May vary between batches)
FormulaC25H19N3O3
SMILESO=C(Nc1cccc2cccnc12)c1ccc(cc1)N1C(=O)C2C3CC(C=C3)C2C1=O
TargetWnt/beta-catenin
SolubilityDMSO:85.8 mg/mL (209.55 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4.1 mg/mL (10.01 mM)

Bioactivity

Target IC50
Wnt:0.2 μM (EC50)|HEK293T cells:26 nM|SW48 cells:2.5 μM (EC50)|HT29 cells:24.4 μM|SW48 cells:0.25 μM
In Vivo
In the Wnt pathway, IWR-1 interacts with Axin to exert a reversible inhibitory effect.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

bcatenin, beta-catenin, betacatenin, inhibit, IWR 1, IWR1, IWR-1, IWR-1-endo, Inhibitor, endo-IWR 1, βcatenin, Wnt/β-catenin, Wnt, Wnt/betacatenin, Wnt/b-catenin

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Quality Guarantee

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Key Properties

No computed properties available.

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IWR-1 (orb1305217)

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5 mg
$ 170.00
25 mg
$ 350.00
DispatchUsually dispatched within 3-5 working days
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