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Ixabepilone

SKU: orb1300396

Description

Ixabepilone is an orally available microtubule-stabilizing agent that binds tubulin, inducing polymerization, G2-M phase arrest, and apoptosis. It is widely used in cancer research, demonstrating activity in both in vitro cell-based assays and in vivo tumor models for studying chemotherapeutic mechanisms.

Research Area

Cell Biology, Infectious Disease & Virology, Signal Transduction

Images & Validation

Key Properties

CAS Number219989-84-1
MW506.7
Purity99.50% (May vary between batches)
FormulaC27H42N2O5S
SMILESC[C@H]1CCC[C@@]2(C)O[C@H]2C[C@H](NC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\c1csc(C)n1
TargetApoptosis,Microtubule Associated,Antibacterial
SolubilityH2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:250 mg/mL (493.39 mM);Ethanol:93 mg/mL (183.54 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.51 mM)

Bioactivity

In Vivo
In vivo, BMS-247550 has clearly demonstrated antitumor activity that is superior to paclitaxel in both paclitaxel-resistant and -sensitive tumors. BMS-247550 is more efficacious compared to paclitaxel in all five paclitaxel-resistant tumors evaluated in this study (four human and one murine): i.e., the clinically derived paclitaxel resistant Pat-7 ovarian carcinoma, the A2780Tax ovarian carcinoma that is resistant to paclitaxel because of tubulin mutations, the HCT116/VM46 MDR colon carcinoma, the clinically derived paclitaxel-resistant Pat-21 breast carcinoma, and the murine fibrosarcoma M5076. Against three paclitaxel-sensitive human tumor xenografts, BMS-247550 produces antitumor activity equivalent to paclitaxel: i.e., A2780 human ovarian carcinoma, HCT116, and LS174T human colon carcinoma.
In Vitro
BMS-247550 is an extremely effective cytotoxic compound that eradicates cancer cells at low nanomolar concentrations. It also preserves its antineoplastic efficacy in human cancers that are either inherently resistant to paclitaxel or have acquired paclitaxel resistance.
Cell Research
HCT116 cells from cultures are collected by trypsinization after 1, 2, 4, 8, 16, and 24 h exposure to 7.5 nm of BMS-247550. Cells are pelleted and fixed in 80% ethanol at −20°C. After an overnight storage at −20°C, cells are rehydrated with PBS buffer and DNA stain by incubation with propidium iodide (5 μg/ml) in 0.1% RNase for 15–30 min. Fluorescence-activated cell sorter acquisition is performed using the FACS Calibur instrument and analysis is done using Cellquest and Modfit software. (Only for Reference)

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, Azaepothilone B, Aza-epothilone B, BMS 247550, BMS 247550-1, BMS247550, BMS-247550, Ixempra, Ixabepilone, inhibit, Inhibitor, MicrotubuleAssociated, Microtubule Associated, Microtubule/Tubulin

Similar Products

  • Ixabepilone [orb1225640]

    >98% (HPLC)

    219989-84-1

    506.6978

    C27H42N2O5S

    5 mg, 10 mg, 25 mg, 2 mg, 1 g, 500 mg, 50 mg, 100 mg, 200 mg
Quality Guarantee

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Key Properties

No computed properties available.

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Ixabepilone (orb1300396)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 100.00
2 mg
$ 140.00
5 mg
$ 240.00
1 ml x 10 mM (in DMSO)
$ 270.00
10 mg
$ 410.00
25 mg
$ 630.00
50 mg
$ 900.00
100 mg
$ 1,190.00
200 mg
$ 1,590.00
DispatchUsually dispatched within 3-5 working days
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