Ixekizumab Antibody

SKU: orb1692306

Description

Ixekizumab

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	1143503-69-8
MW	146.2 kDa
Purity	98.86% (SEC-HPLC)
Target	IL Receptor,Interleukin

Bioactivity

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In Vivo

Ixekizumab (0.001-1 mg/kg; i.v.; C57BL/6 mice) exhibits a dose-dependent reduction in the secretion of keratinocyte chemoattractant (KC) induced by human IL-17A in the plasma of C57BL/6 mice. In male cynomolgus monkeys, intravenous (IV) administration of 1 mg/kg results in a mean elimination half-life of 6.5 days. Subcutaneous (SC) administration of 1 mg/kg yields a maximum plasma concentration of approximately 11.1 µg/mL around 72 hours post-dose, with a mean elimination half-life of about 10.3 days.

In Vitro

Ixekizumab (0.1-10000 pM) dose-dependently inhibits the secretion of growth-regulated oncogene (GRO)α induced by human IL-17A or human IL-17A/F heterodimers from HT-29 cells. Similarly, Ixekizumab demonstrates dose-dependent inhibition of GROα secretion from HT-29 cells induced by cynomolgus monkey IL-17A. The equilibrium KD values of Ixekizumab for IL-17A in humans and cynomolgus monkeys were 1.8 pM and 0.8 pM, respectively. Ixekizumab exhibited binding to rabbit IL-17A as well, although with a lower affinity and heterogeneous binding (with KD values of 1.3 nM and 14 nM, respectively). Notably, Ixekizumab did not demonstrate any binding to IL-17A in either mice or rats.

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Ixekizumab, IL-17A, ILReceptor, LY 2439821, LY2439821, LY-2439821, Interleukin Related, IL Receptor

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Gene Symbol

IL Receptor,Interleukin

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