Izalontamab Antibody

SKU: orb1980400

Description

Izalontamab (SI-B001) is a bispecific antibody targeting EGFR and HER3, designed to inhibit both EGFR homodimers and EGFR/HER3 heterodimers to block oncogenic signaling. It is used in research for advanced epithelial cancers like NSCLC and HNSCC, with studies demonstrating its activity in both in vitro and in vivo models.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	2559704-24-2
MW	197.21 kDa
Purity	99.20%
Target	HER,EGFR

Bioactivity

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In Vivo	Izalontamab (5-46 mg/kg, intravenous injection, once every 7 days for a total of 4 doses) demonstrated significant antitumor efficacy in female NOD/SCID mice bearing SW48, FaDu, and KYSE-150 parazacco spilurus subsp. spilurus xenograft tumors. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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SIB001, SI-B001

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Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

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Gene Symbol

HER,EGFR

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