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Description
Research Area
Cancer Biology, Cell Biology, Immunology & Inflammation, Signal Transduction
Images & Validation
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| Application Notes |
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Key Properties
−| Source | E. coli |
|---|---|
| Biological Activity | Induces apoptosis in vitro in different human cancer cell lines with an EC50 of 5-200ng/ml, depending on the individual cell line used. Recombinant izTRAIL does not kill 4-day cultures of primary human hepatocytes (PHH) at concentrations of at least up to 1ug/ml (Ganten 2006). Good bioavailability in vivo, shows no toxic effects in mice at doses of at least up to 500ug per day (Wissink 2006). |
| Target | TNFSF10 |
| Tag | isoleucine zipper motif Tag |
| Purity | >95% (SDS-PAGE). Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza). |
| Protein Sequence | The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to an isoleucine zipper motif. |
Storage & Handling
−| Storage | Stable for at least 6 months after receipt when stored at -20°C. |
|---|---|
| Form/Appearance | Lyophilized |
| Buffer/Preservatives | Contains 20mM TRIS-Cl, 0.5M arginine-HCl, 100mM NaCl, 0.02% Tween 20. Reconstitute with 100 μl sterile water. |
| Concentration | 0.1mg/ml after reconstitution. |
| Expiration Date | 6 months from date of receipt. |
| Disclaimer | For research use only |
Alternative Names
−Apo-2L, TNFSF10, CD253
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Protocol Information
izTRAIL, Soluble Recombinant Protein (orb1230153)
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