J-113863

SKU: orb1309532

Description

J-113863 is a potent and selective CCR1 antagonist with species-specific activity, showing high affinity for human CCR1 (IC50 0.9 nM) and mouse CCR1 (IC50 5.8 nM). It also antagonizes human CCR3 but is much less active on the mouse ortholog, and is inactive against several other chemokine and inflammatory receptors. This profile makes it a valuable research tool for studying CCR1-mediated pathways in inflammation, autoimmunity, and fibrosis in both cellular and animal models.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Images & Validation

−

Key Properties

−

CAS Number	353791-85-2
MW	655.44
Purity	95.11% (May vary between batches)
Formula	C₃₀H₃₇Cl₂IN₂O₂
SMILES	[I-].CC[N+]1(C\C2=C\CCCCCC2)CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc12
Target	CCR
Solubility	DMSO:6.56 mg/mL (10.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.53 mM)

Bioactivity

−

Target IC50	CCR3:0.58 nM (IC50, Human CCR3)\|CCR3:460 nM (IC50, Mouse CCR3)\|CCR1:0.9 nM (IC50, Human CCR1)\|CCR1:5.8 nM (IC50, Mouse CCR1)
In Vivo	J-113863 treatment improves paw inflammation and joint damage, and dramatically decreases cell infiltration into joints in arthritic mice.
In Vitro	The chemotaxis of the following cells were inhibited by J-113863. Modified Vaccinia virus Ankara (MVA) but not MVA and vaccinia virus (VACV) infected MH-S cells increase the expression of the CXCR2 acting chemokine CXCL2. MH-S cells constitutively produce CCL2 and CCR1 acting chemokines CCL3, CCL5 and CCL9. Consequently, supernatants of mock treated and virus infected MH-S cells induce chemotaxis of murine promyelocyte MPRO cells and human monocytic THP-1 cells at the same level. However, supernatants of MVA infected MH-S cells significantly increase chemotaxis of the CCR2 deficient human monocytic cell line U-937. Read more...

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

collagen, CCR1, CCR, CC chemokine receptor, CCR3, Chemotaxis, CD18, arthritis, anti-inflammatory, Inhibitor, inhibit, J 113863, J113863, J-113863, rheumatoid

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

6918496 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

J-113863 (orb1309532)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

CAS Number:	202796-42-7
MW:	655.44
Formula:	C₃₀H₃₇Cl₂IN₂O₂

CAS Number:	202796-41-6
MW:	655.44
Formula:	C₃₀H₃₇Cl₂IN₂O₂

Purity:	>98% (HPLC)
CAS Number:	353791-85-2
MW:	655.44
Formula:	C₃₀H₃₇Cl₂IN₂O₂

J-113863

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

trans-J-113863 [orb2283354]

cis-J-113863 [orb2283355]

J-113863 [orb1219516]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

J-113863 (orb1309532)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors