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JAK-IN-3

SKU: orb1709378

Description

JAK-IN-3 is a potent small molecule inhibitor targeting JAK3, JAK1, TYK2, and JAK2 kinases. It is a valuable research tool for investigating immune-mediated diseases, supporting both in vitro enzymatic assays and in vivo models of inflammation and autoimmunity.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1400876-94-9
MW340.38
Purity98.19% (May vary between batches)
FormulaC18H20N4O3
SMILESN([C@@H]([C@@H](C)O)CO)C=1C=2N(C=C(C2)C3=CC=CC=C3)N=CC1C(N)=O
TargetJAK
Solubility10% DMSO+90% Saline:2.5 mg/mL (7.34 mM);DMSO:50 mg/mL (146.89 mM)

Bioactivity

Target IC50
TYK2:34 nM|JAK3:3 nM|JAK1:5 nM|JAK2:70 nM
In Vitro
JAK-IN-3 is a potent JAK inhibitor with IC50 values of 3 nM, 5 nM, 34 nM, and 70 nM for JAK3, JAK1, TYK2, and JAK2, respectively.

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Tyk2, JAK3, JAKIN3, JAK-IN-3, JAK2, JAK1, JAK IN 3, JAK
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

JAK-IN-3 (orb1709378)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 180.00
2 mg
$ 240.00
5 mg
$ 380.00
1 ml x 10 mM (in DMSO)
$ 420.00
10 mg
$ 590.00
25 mg
$ 1,130.00
50 mg
$ 1,770.00
100 mg
$ 2,860.00
200 mg
$ 3,820.00
DispatchUsually dispatched within 5-10 working days
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