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JAK1/STAT3-IN-1

SKU: orb2944713

Description

JAK1/STAT3-IN-1 (4f) is a small molecule inhibitor of the JAK1/STAT3 pathway, demonstrating anti-atopic dermatitis activity with an IC50 of 2.17 μM against NO production in vitro. In vivo, it alleviates AD-like skin lesions in MC903-induced mice by reducing inflammatory infiltration and downregulating p-JAK1 and p-STAT3 expression.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

MW548.67
FormulaC30H33FN4O3S
TargetJAK,STAT

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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JAK1/STAT3-IN-1 (orb2944713)

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