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JPE-1375

SKU: orb1982752

Description

JPE-1375 is a potent and selective C5aR1 antagonist, with in vivo studies demonstrating its efficacy in inhibiting neutrophil mobilization (EC50=6.9 µM) and reducing TNF-α levels (EC50=4.5 µM) in mice. This makes it a valuable research tool for investigating the complement system in autoimmune and inflammatory disease models.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number1254036-23-1
MW955.08
FormulaC49H63FN10O9
SMILESC([C@@H](NC([C@H](CC1=CC=CC=C1)NC(=O)[C@@H]2CC(=O)NC(=O)N2)=O)CCCN)(=O)N3[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(F)C=C4)C(N[C@@H](CC5=CC=CC=C5)C(N)=O)=O)=O)CCC(C)C)=O)CCC3
TargetComplement System,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

JPE-1375 (orb1982752)

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