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Karacoline

SKU: orb1297311

Description

Karacolinem is a natural small molecule that inhibits extracellular matrix degradation in intervertebral disc degeneration by targeting the NF-κB signaling pathway. It is a useful research tool for studying IDD mechanisms in both cellular and animal models of disc degeneration.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number39089-30-0
MW377.52
Purity99.75%
FormulaC22H35NO4
SMILES[H][C@]12C[C@]3([H])[C@]([H])([C@H]1O)[C@](O)(C[C@@H]2OC)C1C[C@@]2([H])C33C1N(CC)C[C@]2(C)CC[C@@H]3O
TargetNF-κB
SolubilityDMSO:30 mg/mL (79.47 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.3 mM)

Bioactivity

In Vitro
From the ethanol extract, six feeding deterrents were isolated by bioassay-guided fractionation. The compounds were identified as chasmanine, crassicauline A, Karacoline, sachaconitine, talatisamine, and yunaconitine from their spectroscopic data. Chasmanine, talatisamine, Karacoline, and sachaconitine exhibited feeding deterrent activity against T. castaneum adults, with EC(50) values of 297.0, 342.8, 395.3, and 427.8 ppm, respectively. Yunaconitine and crassicauline A also possessed feeding deterrent activity against T. castaneum adults, with EC(50) values of 653.4 and 1134.5 ppm, respectively.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NFkB, NF-κB, NFκB, NF-kB, Karacoline, inhibit, Inhibitor

Similar Products

  • Karacoline [orb1218072]

    >98% (HPLC)

    39089-30-0

    377.52

    C22H35NO4

    10 mg, 5 mg, 25 mg, 100 mg, 50 mg, 1 g, 500 mg, 200 mg
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Key Properties

No computed properties available.

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Karacoline (orb1297311)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 110.00
5 mg
$ 210.00
1 ml x 10 mM (in DMSO)
$ 220.00
10 mg
$ 310.00
25 mg
$ 490.00
50 mg
$ 690.00
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