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kauran-1617-diol

SKU: orb1221310

Description

Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages.

Images & Validation

Key Properties

CAS Number16836-31-0
MW306.48
Purity>98% (HPLC)
FormulaC20H34O2
SMILESCC1(C)CCC[C@@]2(C)[C@@H]3CC[C@@H]4C[C@]3(C[C@]4(O)CO)CC[C@H]12
TargetOthers
SolubilityDMSO:10 mM

Bioactivity

In Vitro
Kauran-16, 17-diol (ent-Kauran-16β, 17-diol) down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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kauran-1617-diol (orb1221310)

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