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Kavain

SKU: orb1220743

Description

Kavain a compound extracted from the Kava plant Piper methysticum is found to be involved in TNF-α expression in human and mouse cells via regulation of transcriptional factors such as NF-kB and LITAF.

Images & Validation

Key Properties

CAS Number3155-48-4
MW230.26
Purity>98% (HPLC)
FormulaC14H14O3
SMILESCOC1=CC(=O)OC(C1)\C=C\c1ccccc1
TargetOthers
SolubilityIn Vitro: DMSO : 50 mg/mL (217.15 mM)

Bioactivity

In Vitro
Two-electrode voltage clamp technique is used to characterize the functional properties of the major anxiolytic kavalactone, Kavain at human recombinant α1β2, β2γ2 L, αxβ2γ2 L, α1βxγ2 L and α4β2δ γ-Aminobutyric acid type A receptors (GABAARs) expressed in Xenopus oocytes. Kavain positively modulates all receptors regardless of the subunit composition, but the degree of enhancement is greater at α4β2δ than at α1β2γ2 L GABAARs. The modulatory effect of Kkavain is unaffected by flumazenil, indicating that Kavain does not enhance GABAARs via the classical benzodiazepine binding site.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Kavain (orb1220743)

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