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Kavain

SKU: orb1301522

Description

Kavain, a bioactive constituent of Piper methysticum (Kava), modulates TNF-α expression by influencing transcriptional regulators like NF-κB and LITAF. This small molecule is a valuable research tool for studying inflammatory pathways and cytokine regulation in both cellular and animal models of inflammation.

Research Area

Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number3155-48-4
MW230.26
Purity99.93% (May vary between batches)
FormulaC14H14O3
SMILESCOC1=CC(=O)OC(C1)C=Cc1ccccc1
TargetGABA Receptor,NF-κB
Solubility10% DMSO+90% Corn Oil:2 mg/mL (8.69 mM);DMSO:45 mg/mL (195.43 mM)

Bioactivity

In Vivo
Kavain treatment in RAW264.7 cells deactivated MyD88 and Akt, inhibited LITAF, and reduced the production of TNF-α, IL-27, and MIG in response to LPS. Similarly, it had a significant in vivo anti-inflammatory effect on wild-type (WT) mice that developed Collagen Antibody Induced Arthritis (CAIA).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

γ-Aminobutyric acid Receptor, Kavain, inhibit, NF-κB, NFκB, NF-kB, NFkB, Inhibitor, GABAReceptor, GABA Receptor, Gamma-aminobutyric acid Receptor

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

Kavain (orb1301522)

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% Tween 80 +
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1 ml x 10 mM (in DMSO)
$ 70.00
10 mg
$ 70.00
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