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KF-31327

SKU: orb1685223

Description

Thioquinapiperifil dihydrochloride is a potent and selective non-competitive PDE-5 inhibitor with an IC50 of 0.074 nM. This investigational compound is used in biochemical research to study PDE5 function and signal transduction pathways in both cellular and animal models of erectile dysfunction and pulmonary hypertension.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number204077-66-7
MW485.05
Purity99.81% (May vary between batches)
FormulaC24H29ClN6OS
SMILESCl.Cl.CCn1c2cc3ncnc(NCc4ccccc4N4CCC(CO)CC4)c3cc2[nH]c1=S
TargetPDE
SolubilityDMSO:112.5 mg/mL (231.93 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.25 mM)

Bioactivity

Target IC50
PDE4:800 nM|PDE5:0.074 nM|PDE1:380 nM|PDE2:670 nM|PDE3:38 nM
In Vitro
Thioquinapiperifil dihydrochloride (KF31327) (0.1-10 μM) inhibits platelet aggregation in a concentration-dependent manner. In the absence of nitroglycerin, higher concentrations of 1 and 10 μM of KF31327 are inhibits platelet aggregation in a concentration-dependent manner. Thioquinapiperifil dihydrochloride (KF31327) shows a significant increase in cyclic GMP at 10 μM. After 5 min incubation, the mean cyclic GMP levels of KF31327-treated cells is 0.95±0.17 pmol/10 8 cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

KF 31327, KF31327, KF-31327, Thioquinapiperifil, Thioquinapiperifil Dihydrochloride, PDE5
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Key Properties

No computed properties available.

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Protocol Information

KF-31327 (orb1685223)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 100.00
5 mg
$ 180.00
1 ml x 10 mM (in DMSO)
$ 200.00
10 mg
$ 240.00
25 mg
$ 360.00
50 mg
$ 460.00
100 mg
$ 620.00
200 mg
$ 810.00
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