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KIN1148

SKU: orb1223307

Description

KIN-1148 is a IRF3 agonist. IN1148 induced dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. Prime-boost immunization of mice with a suboptimal dose of a monovalent pandemic influenza split virus H1N1 A/California/07/2009 vaccine plus KIN1148 protected against a lethal challenge with mouse-adapted influenza virus (A/California/04/2009) and induced an influenza virus-specific IL-10 and Th2 response by T cells derived from lung and lung-draining lymph nodes.

Images & Validation

Key Properties

CAS Number1428729-56-9
MW361.44
Purity>98% (HPLC)
FormulaC19H11N3OS2
SMILESO=C(NC1=NC2=CC=C3C(N=CS3)=C2S1)C4=CC5=C(C=C4)C=CC=C5
TargetFLT3
SolubilityDMSO : ≥ 100 mg/mL. 276.67 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

KIN-1148 | KIN 1148 | KIN1148

Similar Products

  • KIN1148 [orb1303282]

    98.98% (May vary between batches)

    1428729-56-9

    361.44

    C19H11N3OS2

    5 mg, 10 mg, 50 mg, 100 mg, 25 mg, 1 mg, 1 ml x 10 mM (in DMSO), 200 mg
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Protocol Information

KIN1148 (orb1223307)

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% DMSO +
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Available Sizes

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200 mg
500 mg
2 mg
$ 330.00
5 mg
$ 600.00
10 mg
$ 890.00
25 mg
$ 1,380.00
50 mg
$ 1,850.00
100 mg
$ 2,490.00