Kv7.2/Kv7.3 agonist 1

SKU: orb2695488

Description

Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2315450-35-0
MW	275.28
Formula	C₁₄H₁₄FN₃O₂
SMILES	O=C(NC1=NC(OCC2=CC=C(F)C=C2)=CC=C1N)C
Target	Potassium Channel

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

Potassium Channel

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