Cart summary

You have no items in your shopping cart.

L-741626

SKU: orb1217631

Description

L-741626 is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively).

Images & Validation

Key Properties

CAS Number81226-60-0
MW340.85
Purity>98% (HPLC)
FormulaC20H21ClN2O
SMILESOC1(CCN(Cc2c[nH]c3c2cccc3)CC1)c(cc1)ccc1Cl
TargetDopamine Receptor
SolubilityDMSO : 40 mg/mL (117.35 mM; Need ultrasonic)

Bioactivity

In Vivo
L-741626 (1.0 mg/kg; i.h.) is effective at shifting to the right the pramipexole dose-response curve in pramipexole-trained male Sprague Dawley rats. Coadministrating Cocaine with the D2 antagonist L-741626 (3 mg/kg; i.p.; 15 min before Cocaine)for 5 days reduces the Cocaine-induced increase in microglial TNF-α production in adult mice.
In Vitro
Intrinsic activities in a functional assay using inhibition of quinpirole stimulation of mitogenesis in human dopamine D2 or D3 receptors transfected into Chinese hamster ovary (CHO) cells, L-741626 is prepared by literature methods (Ki (D2)=11.2 nM) and displays a D3/D2 and D4/D2 selectivity ratio of 15-fold and 136-fold, respectively. In the functional assay L-741626 is a potent antagonist (EC50 (D2)=4.46 nM) with some D2 selectivity (EC50 (D3)=90.4 nM).

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole

Similar Products

  • L-741626 [orb1308146]

    98.90%

    81226-60-0

    340.85

    C20H21ClN2O

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 200 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

L-741626 (orb1217631)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

200 mg
500 mg
5 mg
$ 90.00
10 mg
$ 140.00
25 mg
$ 230.00
50 mg
$ 400.00
100 mg
$ 620.00