L-741626

SKU: orb1308146

Description

L-741626 is a selective D2 dopamine receptor antagonist, with Ki values of 2.4, 100, and 220 nM for human D2, D3, and D4 receptors, respectively. This compound is a valuable research tool for investigating dopaminergic signaling in both in vitro binding assays and in vivo behavioral studies related to psychosis and movement.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	81226-60-0
MW	340.85
Purity	98.90%
Formula	C₂₀H₂₁ClN₂O
SMILES	OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)cc1
Target	Dopamine Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.87 mM);DMSO:40 mg/mL (117.35 mM)

Bioactivity

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Target IC50	D2 receptor (human):(ki)2.4 nM\|D4 receptor (human):220 nM(ki)\|D3 receptor (human):100 nM(ki)
In Vivo	In pramipexole-trained male Sprague Dawley rats, L-741626 (1.0 mg/kg; i.h.) is effective at shifting to the right the pramipexole dose-response curve . Coadministration Cocaine with the D2 antagonist L-741626 (3 mg/kg; i.p.; 15 min before Cocaine) for 5 days decreases the Cocaine-induced enhance in microglial TNF-α production in adult mice . Read more...
In Vitro	L-741626 is an effective antagonist (EC50 (D2)=4.46 nM) with some D2 selectivity (EC50 (D3)=90.4 nM), in the functional assay. L-741626 is prepared by literature methods (Ki (D2)=11.2 nM). L-741626 also shows a D3/D2 and D4/D2 selectivity ratio of 15-fold and 136-fold, respectively. Intrinsic activities using inhibition of quinpirole stimulation of mitogenesis in human dopamine D2 or D3 receptors transfected into Chinese hamster ovary (CHO) cells, in a functional assay . Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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L 741626, inhibit, Inhibitor, human D2 receptor, human D3 receptor, human D4 receptor, L741626, L-741626, DopamineReceptor, Dopamine, dopamine, Dopamine Receptor, 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole, TNF-α, production, selective, receptor

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Compound Identifiers

PubChem CID

133633 ↗

Key Properties

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No computed properties available.

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L-741626 (orb1308146)

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Purity:	>98% (HPLC)
CAS Number:	81226-60-0
MW:	340.85
Formula:	C₂₀H₂₁ClN₂O

L-741626

Description

Research Area

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Key Properties

Bioactivity

Storage & Handling

Alternative Names

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