L-Ascorbic acid 2-phosphate magnesium

SKU: orb1307043

Description

L-Ascorbic acid 2-phosphate magnesium is a stabilized vitamin C derivative that functions as an antioxidant and promotes collagen synthesis. It is widely used in cell culture research to enhance extracellular matrix production and has been shown to stimulate hepatocyte growth factor (HGF) in both in vitro and in vivo studies.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	113170-55-1
MW	289.53
Purity	100.00%
Formula	C₆H₉O₉P.3/2Mg
SMILES	C([C@@H]([C@@H]1C(=C(C(=O)O1)OP(=O)([O-])[O-])O)O)O.[Mg+2]
Target	ROS,Phosphorylase,Endogenous Metabolite,Phosphatase,Reactive Oxygen Species
Solubility	H2O:20.83 mg/mL (71.94 mM);DMSO:Slightly soluble

Bioactivity

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In Vitro

L-Ascorbic acid 2-phosphate (50 μM-250 μM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 μM AsA2-P and 10 nM dexamethasone (Dex), and 250 μM AsA2-P and 5 nM Dex.L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc) achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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alkaline phosphatase, 2-Phospho-L-ascorbic acid magnesium, derivative, differentiation, osteogenic, inhibit, L Ascorbic acid 2 phosphate magnesium, Inhibitor, hASC, medium, LAscorbic acid 2phosphate magnesium, L-Ascorbic acid 2-phosphate magnesium, Endogenous Metabolite, Reactive Oxygen Species, Phosphatase, supplement, runx2A, vitamin

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Compound Identifiers

PubChem CID

54679072 ↗

Key Properties

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No computed properties available.

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