Lactic acid

SKU: orb1680007

Description

Lactic acid (2-hydroxypropanoic acid) is an endogenous agonist of the hydroxycarboxylic acid receptor 1 (HCAR1) with an EC50 of 4.2-5 mM. This glycolysis product is utilized in research areas including immunometabolism and tumor biology, serving as a key metabolite for in vitro and in vivo studies of cellular energetics and signaling.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

−

Key Properties

−

CAS Number	50-21-5
MW	90.08
Purity	99.45% (May vary between batches)
Formula	C₃H₆O₃
SMILES	O=C(O)C(O)C
Target	Others,Endogenous Metabolite,HCAR
Solubility	DMSO:90 mg/mL (999.11 mM);H2O:100 mg/mL (1110.12 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (55.51 mM)

Bioactivity

−

Target IC50	GPR109B:1 mM (EC50)\|GPR109A:1 mM (EC50)\|GPR81 (HCAR1):1 mM (EC50)
In Vivo	METHODS: To detect the anti-tumor activity in vivo, Lactic acid (1.6 g/kg) was subcutaneously injected into Female C57BL/6 mice with MC38 colon cancer cells; pH 7.4 Once a day; From Day 8 to Day 30. RESULTS: Lactic acid demonstrated CD8+ T cell-dependent tumor growth inhibition in the MC38 colon cancer model.
In Vitro	METHODS: : Effects on cell proliferation and migration of uveal melanoma after treatment with Lactic acid (20 mM) for 24 and 48 hours. RESULTS: Lactic acid led to a significant reduction in cell proliferation and migration. Method: Uveal melanoma was treated with Lactic acid (20 mM) for 24 hours, and the protein expression level was detected by western blot. Result: Lactic acid promoted the increase in the protein expression levels of MCT1 and HCAR1.

Storage & Handling

−

Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

2-hydroxypropanoic acid, Lactic acid

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

612 ↗

Key Properties

−

No computed properties available.

Protocol Information

Find More Protocols

Reactivity:	All
Dynamic Range:	9.38-600 µg/mL
Sensitivity:	2.96 µg/mL

Applications:	ELISA
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Reactivity:	All
Dynamic Range:	30 μmol/L - 600 μmol/L

Purity:	99.85% (May vary between batches)
CAS Number:	79-33-4
MW:	90.08
Formula:	C₃H₆O₃

Lactic acid

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

General Lactic Acid (LA) ELISA Kit [orb782046]

Lactic acid bacterial surface protein Rabbit Polyclonal Antibody [orb6284]

Lactate Dehydrogenase Assay Kit [orb219863]

Lactate Dehydrogenase-Cytotoxicity Colorimetric Microplate Assay Kit [orb3073197]

L-Lactic acid [orb1302516]

Quality Guarantee

Compound Identifiers

Key Properties

Protocol Information

Available Sizes

Email

UK Office

US Office

CN Office

Distributors