Lamotrigine

SKU: orb1310392

Description

Lamotrigine (BW430C) is a small molecule anticonvulsant and mood stabilizer that functions by inhibiting voltage-gated sodium channels, thereby reducing neuronal hyperexcitability. It is widely used in neuroscience research for studying epilepsy and bipolar disorder mechanisms in both in vitro electrophysiology and in vivo animal models.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	84057-84-1
MW	256.09
Purity	99.76% (May vary between batches)
Formula	C₉H₇Cl₂N₅
SMILES	NC1=NN=C(C(N)=N1)C1=CC=CC(Cl)=C1Cl
Target	Autophagy,5-HT Receptor,Sodium Channel
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.81 mM);DMSO:43.33 mg/mL (169.2 mM);Ethanol:2.6 mg/mL (10.15 mM)

Bioactivity

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Target IC50	5-HT (rat brain synaptosomes):474 μM\|5-HT (human platelets):240 μM
In Vivo	In rat cortical brain tissues cultured with 10 mg/L veratridine, Lamotrigine inhibited the release of glutamate and aspartate (both with an ED50 of 5.38 mg/L) twice as effectively as it inhibited the release of GABA (ED50 of 11.2 mg/L), without affecting the basal release of glutamate. Lamotrigine stabilizes presynaptic neuronal membranes by blocking voltage-dependent sodium channels, thereby preventing the release of excitatory neurotransmitters, especially glutamate and aspartate. It does not induce phencyclidine (PCP)-like central nervous system effects, does not act through direct inhibition of NMDA receptors, and may avoid the adverse effects associated with NMDA blockade. Read more...
In Vitro	Lamotrigine is active in electrically induced EEG after-discharge tests, indicating its ability to counteract simple and complex partial seizures. It demonstrates antiepileptic effects in mice and rats, preventing hind-limb extension induced by both MES (maximal electroshock) and pentylenetetrazole. The peak effects of Lamotrigine occur 1 hour post-administration, with a duration exceeding 24 hours. Intravenous administration of Lamotrigine at doses greater than 5 mg/kg in rats results in a dose-dependent reduction in after-discharge duration. Read more...

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Autophagy, BW430C, 5-HT (human platelets), 5-HT (rat brain synaptosomes), 5HTReceptor, 5HT Receptor, inhibit, Na+ channels, Na channels, LTG, Lamotrigine, Lennox-Gastaut syndrome, Inhibitor, focal seizure, epilepsy, tonic-clonic seizure, Sodium Channel, SodiumChannel, seizure

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Compound Identifiers

PubChem CID

3878 ↗

Key Properties

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No computed properties available.

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Lamotrigine (orb1310392)

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CAS Number:	375347-20-9
MW:	274.11
Formula:	C₉H₉Cl₂N₅O

CAS Number:	113170-86-8
MW:	382.22
Formula:	C₁₁H₁₃Cl₂N₅O₄S

Purity:	>98% (HPLC)
CAS Number:	934240-30-9
MW:	314.3541
Formula:	C₁₈H₁₉FN₂O₂

Purity:	>98% (HPLC)
CAS Number:	84057-84-1
MW:	256.09
Formula:	C₉H₇Cl₂N₅

Lamotrigine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Lamotrigine (orb1310392)

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