Larsucosterol trimethylamine

SKU: orb1983172

Description

Larsucosterol trimethylamine (DUR-928) is a liver X receptor (LXR) antagonist with epigenetic modulatory activity. It reduces hepatic lipid accumulation, suppresses LPS- and TNFα-driven inflammation in macrophages, and demonstrates protective effects in models of LPS- and acetaminophen-induced organ injury.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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MW	541.83
Purity	97.00% (May vary between batches)
Formula	C₃₀H₅₅NO₅S
SMILES	C[C@@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]3[C@H]2CC=C4[C@]3(C)CC[C@H](OS(=O)(O)=O)C4)CCCC(C)(O)C.CN(C)C
Target	Liver X Receptor,Endogenous Metabolite
Solubility	10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (3.69 mM);DMSO:20 mg/mL (36.91 mM)

Bioactivity

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In Vivo

In a mouse hepatectomy model, larsucosterol upregulates the expression of genes associated with cell replication, including Wt1 (Wilms’ tumor 1),PCNA (proliferating cell nuclear antigen), cMyc (myelocyto-matosis oncogene), cyclin A, FoxM1b (Forkhead Box M1b),and CDC25b (M-phase inducer phosphatase 2), whereas con-currently downregulating the expression of cell cycle arrestgene Chek2 (checkpoint kinase 2) and the apoptotic geneApaf1 (apoptotic peptidase activating factor 1).

In Vitro

In a model of HG-induced MASLD in humanhepatocytes, Larsucosterol exhibits a specific inhibition of DNMTs. This results in the conversion of 5mCpG to CpG in the promoter regions of 1,074 genes within hepatocytes, leading to the upregulation of genes associated with key sig-naling pathways such as MAPK-ERK, calcium-AMPK, andtype II diabetes mellitus pathways.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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DV-928 trimethylamine, DUR-928 trimethylamine, LXR, Liver X Receptor, LiverXReceptor

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Compound Identifiers

PubChem CID

166638328 ↗

Key Properties

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No computed properties available.

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