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LASSBio-1135

SKU: orb1298933

Description

LASSBio-1135

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number852453-71-5
MW286.33
Purity99.09%
FormulaC18H14N4
SMILESN(C1=C(N=C2N1C=CC=C2)C3=CC=CC=N3)C4=CC=CC=C4
TargetTNF,TRP/TRPV Channel
SolubilityDMSO:2.87 mg/mL (10.02 mM)

Bioactivity

In Vivo
Oral administration of 100 mol x Kg(-1) LASSBio-1135 markedly reduced thermal hyperalgesia induced by carrageenan, however at 10 mol x Kg(-1) only a partial reduction was observed at the 4th h. Neutrophil recruitment and TNF-α production after carrageenan stimulus was also inhibited by the treatment with LASSBio-1135. Modulating TRPV1 and TNF-α production, two key therapeutic targets of neuropathic pain, 100 mol x Kg(-1) LASSBio-1135 was orally efficacious in reversing thermal hyperalgesia and mechanical allodynia produced by partial sciatic ligation 7-11 days after surgery without provoking hyperthermia, a common side effect of TRPV1 antagonists.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

LASSBio 1135, LASSBio1135, LASSBio-1135, TNF-α, TRPV Channel, TRPChannel, TRP Channel, TRPV1, TRPVChannel

Similar Products

  • LASSBio-1135 [orb1220125]

    >98% (HPLC)

    852453-71-5

    286.33

    C18H14N4

    1 g, 500 mg, 200 mg, 2 mg, 50 mg, 100 mg, 10 mg, 25 mg, 5 mg
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Key Properties

No computed properties available.

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LASSBio-1135 (orb1298933)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 140.00
5 mg
$ 290.00
10 mg
$ 420.00
25 mg
$ 680.00
50 mg
$ 940.00
100 mg
$ 1,220.00
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