Lazertinib mesylate hydrate

SKU: orb3174985

Description

Lazertinib (YH25448) mesylate hydrate is a potent, selective, orally available, and irreversible EGFR tyrosine kinase inhibitor capable of crossing the blood-brain barrier. It exhibits high selectivity toward activating EGFR mutations (EGFRm) and T790M-resistant mutations. Lazertinib mesylate hydrate effectively inhibits the phosphorylation of EGFR, AKT, and ERK, leading to the induction of apoptosis and suppression of tumor growth in mouse models of H1975-luc brain metastases xenografts. This compound is applicable in the study of non-small cell lung cancer.

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Key Properties

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CAS Number	2411549-88-5
MW	668.77
Formula	C₃₁H₄₀N₈O₇S
SMILES	O=C(C=C)NC1=CC(NC2=NC=CC(=N2)N3N=C(C=4C=CC=CC4)C(=C3)CN(C)C)=C(OC)C=C1N5CCOCC5.O=S(=O)(O)C.O
Target	EGFR,Apoptosis,Akt,ERK

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

EGFR,Apoptosis,Akt,ERK

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