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LD4172

SKU: orb2945672

Description

LD4172 is a potent VHL-based PROTAC that induces RIPK1 degradation with nanomolar DC50. It promotes TNF-α-induced apoptosis in B16F10 cells in vitro and exhibits antitumor efficacy in mouse models, supporting its use in studying necroptosis and oncology research.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number2782022-40-4
MW1149.37
FormulaC61H75F3N10O7S
SMILESNC1=C2C(=CN(CCCNC(CCCCCCCCCCC(N[C@H](C(=O)N3[C@H](C(N[C@@H](C)C4=CC=C(C=C4)C=5SC=NC5C)=O)C[C@@H](O)C3)[C@](C)(C)C)=O)=O)C2=NC=N1)C=6C=C7C(=CC6)N(C(CC8=CC(OC(F)(F)F)=CC=C8)=O)CC7
TargetRIP kinase,PROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Protocol Information

LD4172 (orb2945672)

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