Leriglitazone hydrochloride

SKU: orb1983413

Description

Leriglitazone (Hydroxypioglitazone) hydrochloride, a pioglitazone metabolite, acts as a PPARγ agonist, effectively stabilizing the PPARγ activation function-2 (AF-2) co-activator binding surface to enhance co-activator binding, which results in a modest improvement in transcriptional efficacy. It binds to the PPARγ C-terminal ligand-binding domain (LBD) with a dissociation constant (K i) of 1.2 μM and demonstrates transcriptional efficacy with an effective concentration (EC 50) of 680 nM.

Research Area

Metabolism Research, Molecular Biology

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Key Properties

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CAS Number	146062-46-6
MW	408.90
Formula	C₁₉H₂₁ClN₂O₄S
SMILES	Cl.CC(O)c1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1
Target	PPAR,Others

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

PPAR,Others

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