Leucomethylene blue mesylate

SKU: orb1300151

Description

TRx0237 mesylate, also known as Leucomethylene blue mesylate, is a second-generation inhibitor targeting tau protein aggregation. It is utilized in research for Alzheimer's and frontotemporal dementia, with studies demonstrating its effects in both cellular and animal models of tauopathy.

Research Area

Neuroscience, Signal Transduction

Images & Validation

−

Key Properties

−

CAS Number	1236208-20-0
MW	477.62
Purity	99.99% (May vary between batches)
Formula	C₁₆H₁₉N₃S·2CH₄O₃S
SMILES	CS(O)(=O)=O.CS(O)(=O)=O.CN(C)c1ccc2Nc3ccc(cc3Sc2c1)N(C)C
Target	Beta Amyloid,Microtubule Associated
Solubility	Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:87 mg/mL (182.15 mM);DMSO:88 mg/mL (184.25 mM)

Bioactivity

−

Target IC50	Tau:0.12 μM (Ki)
In Vivo	Leucomethylene blue dose-dependently rescues the learning impairment and restores behavioral flexibility in a spatial problem-solving water-maze task in L1 (minimum effective dose: 9 mg MT/kg for TRx0237) and correctes motor learning in L66 (effective doses: 4 mg MT/kg). It reduces the number of tau-reactive neurons, particularly in the hippocampus and entorhinal cortex in L1 and in a more widespread manner in L66. Read more...
In Vitro	Leucomethylene blue is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. It is a purified forms of Methylene Blue, an old drug that predates the FDA and is being widely used in Africa for the treatment for malaria as well as for methemoglobinemia and other conditions. An in vitro study showed the ability of Leucomethylene blue in disrupting PHFs(paired helical filaments) isolated from Alzheimer's Disease brain tissues at the concentration at 0.16 μM. Read more...

Storage & Handling

−

Storage	keep away from direct sunlight,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Disease, Beta Amyloid, BetaAmyloid, Amyloid-β, bAmyloid, Aβ25-35, b Amyloid, Alzheimer's, aggregation, Abeta, inhibit, Methylene blue leuco base, Methylene blue leuco base Mesylate, Methylene blue leuco base mesylate salt, Microtubule Associated, MicrotubuleAssociated, Inhibitor, Leucomethylene Blue, Leucomethylene blue, Leucomethylene Blue Dimesylate, Leucomethylene blue Mesylate, Leucomethylene blue mesylate, Tau aggregation, Tau, βAmyloid, β Amyloid, β-amyloid peptide, TRx 0237, TRx0237, TRx-0237, TRx0237 (LMTX) Mesylate, TRx0237 (LMTX) mesylate, TRx0237 mesylate, TRx0237 Mesylate

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

60150609 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols